The Premier League is back in focus following the Champions League action, and there are a couple of high-profile managers casting a nervous eye the way of their treatment room.
Arsenal boss Arsene Wenger saw Jack Wilshere limp out of his side's loss to Borussia Dortmund, while Manchester United striker Robin van Persie was given a rest against Real Sociedad as he looks to overcome toe and groin issues.
The following are the latest injury reports for each Premier League fixture on the schedule from October 26 to 27.
Arsenal visit Crystal Palace, and along with the worry over Wilshere, the Gunners have a host of players—Theo Walcott among them—on the sidelines.
Aston Villa face Everton and will be boosted by the return of Christian Benteke. Paul Lambert will also hope Ciaran Clark can shake off illness to feature. Everton have no fresh problems.
Liverpool take on West Brom, with the game likely to come too soon for Philippe Coutinho. Jose Enrique remains a doubt with a knee problem.
Manchester United play host to Stoke City, and Robin van Persie is likely to return after sitting out the midweek win over Real Sociedad to nurse toe and groin problems.
Cardiff travel to Norwich with no fresh injury concerns, while the Canaries will hope star striker Ricky van Wolfswinkel can shake off an ankle niggle.
Southampton entertain Fulham with the luxury of a clear treatment room, while Fulham have defensive worries over Brede Hangeland and Aaron Hughes.
Little extra spice is needed for a North East derby, but this one arrives with Sunderland rooted to the foot of the table and with a new manager in place. Wes Brown is the only notable worry for the Black Cats, while Newcastle have concerns over captain Fabricio Coloccini who missed the draw with Liverpool last weekend.
A massive clash of title contenders takes place at Stamford Bridge as Chelsea face Manchester City. The Blues have worries over Ashley Cole, while Vincent Kompany is not fit to return for City.
Swansea take on West Ham with manager Michael Laudrup looking for Ashley Williams to brush off a knock. West Ham are still without Andy Carroll.
Hull make the trip south to face Tottenham without striker Danny Graham, while Tottenham will have Andros Townsend, Paulinho and Kyle Walker at full tilt after they were rested for the Europa League trip to Sheriff Tiraspol.