Arsenal will be looking to win their third Champions League match in as many attempts, as Schalke will try to knock the Gunners off the top of the table in Group B.
The German side currently sits third in the Bundesliga and boasts a talented attack capable of beating the Arsenal defense.
But the Gunners have several creative players that thrive while going forward as well, and the overall talent on the pitch will ensure a thrilling match.
Here is everything you need to now about this UCL fixture.
Where: Emirates Stadium, London, United Kingdom
When: Wednesday, Oct. 24, 2:45 p.m. ET
Live Stream: Fox Soccer 2Go
Biggest Storyline: Group B Supremacy
At this stage, Arsenal and Schalke appear to be the teams that will finish in the top two spots, but this game will have a significant effect on the order in which they place.
If the Gunners can win the match, they will move five points clear of Schalke and take a significant lead in the group. But the Germans can take the lead with a victory, and the path to the knockout stage will be significantly clearer when the final whistle blows.
Player to Watch for Arsenal: Santi Cazorla
The Spanish midfielder is having a tremendous season and has been Arsenal’s most dangerous player thus far.
His piercing passes and thumping shots allow him to be extremely dangerous as both a scorer and a distributor. His intelligent movement without the ball creates confusion for the defense and he is a constant threat whenever he is on the pitch.
Player to Watch for Schalke: Klaas-Jan Huntelaar
The imposing Dutch striker is tall, strong, skilled and powerful. He is a consummate center forward and will put persistent pressure on the heart of the Gunners’ defense.
He has hit the back of the net in each of Schalke’s first two Champions League matches and has an excellent chance to keep that goal-scoring record going in London.
What They’re Saying
Goal.com’s Alfie Meekings went through the lengthy list of injuries that Arsene Wenger will be longingly looking over as he tries to piece together a lienup.
Arsene Wenger’s injury list continues to grow, as a knock to Alex Oxlade-Chamberlain (hip) in Saturday’s defeat to Norwich means he joins Bacary Sagna (leg), Theo Walcott (rib), Laurent Koscielny (back) and Abou Diaby (thigh) on the sidelines.
Kieran Gibbs may be passed fit after suffering with a thigh strain, but it is unlikely that he will be risked ahead of Andre Santos.
One piece of more pleasing news for Arsenal is the return of Jack Wilshere to fitness. However, after playing 90 minutes for the Gunners’ Under-21s on Monday, it is unlikely that he will feature.
The Guardian’s Kevin McCarra notes that Arsenal’s fantastic home record against in UCL matches give the Gunners an advantage, but that does not mean they will take Schalke lightly.
Arsenal are at ease when facing some of Europe's most formidable clubs. The side have lost only one of their previous 44 Champions League matches at home and that defeat only came in a semi-final, against Manchester United in 2009. Given those circumstances, the hosts are unlikely to panic about the arrival of Schalke on Wednesday but the visitors do present a genuine danger.
What will happen?
Prediction: Arsenal 2, Schalke 1
Despite a terrible showing in the Premier League this past weekend, the Gunners will play well in front of a home crowd and ensure that they take maximum points through their first three Champions League matches.