Clemson Tigers vs. Boston College Eagles: Odds, College Football Betting Pick

Clemson owns seven straight wins in the series with Boston College, but the Eagles are 4-3 against the spread over that span, keeping several games close as underdogs. Boston College is getting a bunch of points again for Saturday evening's big game with the Tigers up in Chestnut Hill.

College football point spread: The Tigers opened as 17.5-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)

College football betting pick, via OddsShark computer: 45.3-25.8 Tigers (College football picks on every game)

Check out the OddsShark podcast on iTunes or Spotify or at OddsShark.libsyn.com for more odds information, betting picks and a breakdown of this week’s top sports betting news.

Why the Clemson Tigers can cover the spread

Clemson reached 9-0 on the season and 4-0 ATS over its last four games with a 77-16 blasting of Louisville last week, covering a 39-point spread. The Tigers scored two touchdowns in the first three minutes of the game, led 35-3 at the half and rolled on from there for the easy win and the money.

On the afternoon, Clemson out-gained the Cardinals 661-312, piling up 492 yards on the ground. The Tigers scored three touchdowns of 55 yards or longer on offense and returned an interception for a touchdown on defense.

Clemson has now out-gained every opponent this season except Texas A&M and out-rushed every opponent except North Carolina State. The Tigers have also won their last four games by the ridiculous combined score of 240-36.

At 6-0 in conference play, Clemson can clinch the ACC's Atlantic Division with a victory Saturday, the first step on the trail back to the College Football Playoff.

Why the Boston College Eagles can cover the spread

The Eagles are 3-0 SU their last three times out and 4-0 ATS their last four, following last week's 31-21 victory/cover at Virginia Tech. Boston College took an early 7-0 lead on the Hokies, then trailed 14-7 at the half. But the Eagles scored the first 21 points out of the locker room to take control, on their way to the win and the cash at what's usually a tough place to play.

On the afternoon Boston College out-rushed Virginia Tech 219-111 and won the turnover battle 2-1, creating a plus-7 point differential.

Two weeks ago, the Eagles beat Miami 27-14, and just before that they defeated Louisville 38-20. So on the season Boston College is 5-0 SU and 4-1 ATS at Alumni Stadium.

At 4-1 in conference play, the Eagles are three wins away from their first ACC Championship Game berth in 10 years.

Smart betting pick

Clemson won this matchup last season 34-7, but Boston College held on for the cover as a 34-point dog. The Eagles also showed some maturity last week, avoiding a letdown after the victory over the Hurricanes. However, the Tigers are steamrolling at the moment, and playing on the road means the spread is a tad more amenable. The smart money here gives the points with Clemson.

College football betting trends

Clemson is 7-0 SU in its last seven games vs Boston College.

The total has gone over in Clemson's last four games on the road.

Clemson is 4-0 ATS in its last four games.

All college football odds and betting trends according to Bleacher Report's official odds partner, OddsShark. Check out OddsShark on Twitter and Instagram or head to YouTube for more betting picks and analysis on this week's top games. You can also download the free odds tracker app.