Manchester United are looking for their first win in this season's Champions League, and against a side manager Alex Ferguson admitted he had "never heard of" before.
Otelul Galati will meet United at Bucharest's National Arena in the biggest match in their 47-year history. United drew 1-1 against Benfica in Lisbon and shared six goals with Basel at Old Trafford in their first two games in Group C.
Here's are my predictions for United's lineup on Tuesday.
David de Gea looks to be the most likely to start against Manchester City this weekend, so Anders Lindegaard will be United's choice in goal, if fit.
Nemanja Vidic looks set to make his return to the United setup after his injury layoff.
"Rio played very well on Saturday but we have Vidic with us here and I felt it was a good opportunity to give Rio a break. Playing three games in seven days is a lot to ask." Sir Alex said.
Phil Jones has been transported all over the place so far this season, but against Otelul Galati I see a return to his favored center back position.
With Rafael Da Silva still a no-show for United, Chris Smalling looks set for another marquee performance at right back for United.
Nani wasn't hugely involved against Liverpool last weekend and, if only to give him game time ahead of the Manchester derby, the Portuguese winger should start against Otelul Galati.
Anderson was an unused sub in United's league game against Liverpool on Saturday, so it is likely that he will be given some match time ahead of United's league game against Manchester City.
The Brazilian has no known fitness issues.
We haven't seen much of Antonio Valencia this season, so with United set for a league clash against Manchester City this weekend, the Ecuadorian could make the cut.
"I think Wayne's ready. When he came on [against Liverpool] I thought he was bubbly, full of energy and enthusiasm, "Sir Alex said about Rooney. "He was desperate to get on, which was good. I think when he started to watch the game he thought, 'I could be out there.' I think he's okay."
United will need a few more like this, so it's likely we'll see Hernandez play. Although, Dimitar Berbatov may get the nod ahead of the Mexican.