Given the historic rivalry between the two teams and the two sets of supporters, it's widely considered to be the biggest game in the Premier League season. And this Saturday, it's United who will be visiting Anfield for this season's first clash between the two most successful clubs in English football.
In March, a resurgent Liverpool beat United at Anfield by three goals to one, with Luis Suarez the catalyst and Dirk Kuyt the decider of that scintillating victory.
After a summer's transfer activity and subsequent squad overhaul, both teams go into this game with much-changed lineups, and this Saturday's game will throw up some thrilling new on-field matchups.
Let's take a look at where the points this weekend might be won, shared or lost.