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Aston Villa's win over Sunderland on Monday will have huge implications for the race to avoid relegation as the team has moved five points clear of 18th-placed Wigan (though Wigan does have a game in hand).
Wigan will face a difficult match of its own on the road against eighth-placed West Brom, while Newcastle will try to remain out of the relegation zone with a winnable game against West Ham.
In the race for the Champions League, the key match will be Chelsea facing Manchester United at Old Trafford. United wasn't at its best over the weekend in a 1-1 draw against Arsenal, getting bossed in the midfield and allowing the Gunners to remain the aggressor, but the Red Devils proved they wouldn't rest on their laurels down the stretch despite clinching the title.
Speaking of Arsenal, the team has a very winnable game at Loftus Road against QPR. The Gunners will probably need nine points from their last three games with both Chelsea and Tottenham holding a game in hand.
Spurs also have a winnable contest, hosting Southampton. Don't be surprised if Arsenal, Chelsea and Tottenham are all separated by just two points after the weekend.