European police claim a Champions League tie played in England was fixed, according to a report on the BBC Sport website.
The fixture is one of 680 games across the globe which was rigged, although Europol have not named which match in England was affected.
Europol, which is the European Union's law enforcement agency, revealed the results of an investigation at a press conference at The Hague in the Netherlands.
An organised crime syndicate based in Asia has been named as the centre of the match-fixing following an enquiry which began 18 months ago with over 400 match officials, players, club officials and criminals believed to be involved.
The match in England took place within the "last three or four years" but Europol refused to comment further with the match still under investigation.
The initial investigation had centred around matches in Germany, Finland and Hungary, but was extended to Slovenia and Austria.
Europol have already made 50 arrests while 80 search warrants have been obtained in relation to the match-fixing investigations.
Other competitions affected by the allegations include World Cup and European Championship qualifiers and games across league games in Europe.
FIFA has issued its reaction to the Europol investigation findings, claiming the issue can only be resolved with the support of all authorities.
Match-fixing is not a new activity in England, with a Malaysian betting syndicate behind floodlight failures at Premier League matches during the late 1990s, as the BBC reported in 1999.
However, such issues have been relatively rare in the British game and the news of a Champions League match on English soil being fixed has come as a shock.
But The Sun newspaper has reported that the Football Association and UEFA knew nothing of the investigations into the matches.