The match between Portugal and Northern Ireland will be between two squads going in opposite directions.
Portugal is the favorite and after a 1-0 defeat at the hands of the Russian team, Cristiano Ronaldo and his team are looking to keep pace at the top of the standings, six points behind first place in the World Cup Qualifying group.
Northern Ireland is at the bottom of the group, hoping to begin what is an impossible climb back into contention.
The Irish had a disappointing draw in their last match with Luxembourg. Northern Ireland had several opportunities to score that were squandered and two of its goals were taken away because of different infractions.
This match will not come without injuries playing a role, however. Northern Ireland is missing key pieces to their team, including Chris Brunt and Shane Ferguson. A suspension will have top defender Gareth McAuley missing from the lineup as well.
To make matters worse for Northern Ireland in this match, they are without many key bench players to fill those holes and will have to rely on less talent and inexperience to pick up the slack.
As for Portugal, its star player, Ronaldo, will be enjoying his 100th career match for his country which is a feat only two other Portuguese players have accomplished.
The Portuguese will also be missing a few top players in this match. Both Fabio Coentrao and Raul Meireles will be missed in this showdown, but Portugal can be thankful they don't have the depth issues of their opponents.
Under new coach Michael O'Neill, Northern Ireland has yet to win a game and O'Neill's squad is averaging three goals allowed per game in that stretch, showing that defense and goalkeeping is not a strength.
Portugal has much more talent on both sides of the ball than their counterparts, making this likely to be a match where Portugal's superior offense has a field day against Northern Ireland. The Irish squad had a mountain to climb already, but there's no doubt it's even bigger with all the injuries to their team.
Here's how to watch this World Cup Qualifying match.
When: Tuesday, Oct. 16 at 3:45 p.m. ET
Where: Estadio Do Dragao, Porto, Portugal
Live Stream: ESPN 3