The hottest match in English football doesn't need much hype.
It has been a difficult couple of weeks for everyone at Liverpool. As the fight for justice continues in the wake of the Hillsborough disaster, a match against the club's fiercest rivals will be a welcome distraction.
Manchester United have already lost once on Merseyside this season. They've struggled at Anfield in recent campaigns and will be content with anything other than a loss.
Plenty of sub-plots could take the headlines here. Luis Suarez and Patrice Evra would be foolish not to shake hands, although the BBC suggests the two will finally put their differences aside.
A handful of United fans mocked the Hillsborough deaths last week at Old Trafford and have been urged to show solidarity with the Liverpool support (via The Daily Mail).
On the pitch we have a cracking match in store.
Brendan Rodgers will be desperate to get his first Premier League win for the Kop. After United's poor Champions League showing against Galatasaray, I think Liverpool will fancy their chances.
If this fixture is played in the correct way, and supporters work together for once, this could be a landmark encounter for the Premier League.
Key Battle: Luis Suarez vs Nemanja Vidic
Vidic has a history of poor performances against Liverpool. He has been sent off twice in this fixture and suffered terribly when Fernando Torres was in the side. Suarez will be the main threat for the hosts. If he can attack in a direct and tricky manner the goals will follow. Vidic doesn't like players who twist and turn around him, making this battle key to the result.