Sergio Alcantara will start in place of Baez at short.
Baez has missed nine games this season, including three straight from June 7-9 because of a hand injury after hitting the ball off the end of his bat against the San Francisco Giants.
Even though the Cubs didn't put Baez on the injured list, the situation was bad enough for him to sit out their series against the San Diego Padres.
Baez can be a difference-maker when healthy, though he's also struggled with consistency in 2021. The two-time All-Star has a .234/.282/.496 slash line with 21 homers and 56 RBI in 77 games.
Baez's absence in the lineup is a big blow to a Cubs squad that is looking to snap an 11-game losing streak, which has caused the team to fall all the way to fourth place in the National League Central. Chicago currently sits 8.5 games behind Milwaukee in the Central and eight games back of San Diego in the NL Wild Card race.