The Nets quickly announced he would not return for the remainder of the game with a facial contusion.
Irving has already missed 17 games this season due to a variety of issues. He most recently sat out Brooklyn's 130-113 win over the Indiana Pacers on April 28 with groin soreness.
The Nets remain in second place in the Eastern Conference despite not having their big three together for most of the year. James Harden has been out of action since April 5 due to a hamstring injury. Kevin Durant missed 23 straight games from Feb. 15-April 5 with a strained hamstring.
Head coach Steve Nash has done an excellent job in his first season keeping the Nets going amid progloned absences by his top stars.
Irving has been fantastic this season when he does play. The seven-time All-Star is averaging 27.4 points on 50.4 percent shooting, 6.2 assists and 4.8 rebounds in 51 starts.
Until Irving is able to return, the Nets will give Landry Shamet and Tyler Johnson extended playing time.