Club America will host the latest edition of El Super Clasico on Saturday against Chivas Guadalajara at the Estadio Azteca in Mexico City.
The Eagles are the favourites ahead of the clash after a terrible campaign for the Goats.
Chivas have won only three games in the Liga MX this season, which triggered the sacking of coach Tomas Boy after only five months in charge.
America are placed in fifth and positioned to qualify for the Clausura, but they cannot afford a defeat to their historical rivals.
Date: Saturday, Sept. 28
Time: 9:05 p.m. (local), 10:05 p.m. (ET), 3:05 a.m. Sunday (BST)
TV: TUDN (Mexico and USA)
Stream: Univision NOW,
Odds: America 83-100, Chivas 17-5, draw 13-5 (per Caesars)
Chivas will journey from Guadalajara to the capital after appointing Luis Fernando Tena on Thursday as their new manager.
The 61-year-old will begin his tenure against the club he managed from 2006-07.
Chivas released a statement about the arrival of "El Flaco" (h/t Tom Marshall of ESPN): "The club confides that the experience, fortitude, and knowledge of 'Flaco' in managing players will be a boost from this moment to return the 'Rabano Sagrado' to the historical position that its tradition and supporters demand."
The away side have won only once in their last five, are 18th in the relegation table and lost 4-2 to Pachuca last time out.
America could only muster a 2-2 draw with Queretaro in their previous game at the Aztec Stadium, but they will like their chances against a Chivas team in full transition.
The hosts have struggled to produce a winning run since the start of the season and are without a victory in their last six, having drawn five and lost once. Their last league victory came on August 18 in a 1-0 win over Monarcas Morelia.
Worryingly for the home side, they do not have any forwards in goalscoring form. Meanwhile, Chivas' Alan Pulido has five goals for the season—and the 28-year-old scored on Wednesday against Pachuca.
Tena's arrival could be the key differential in the match, and a fresh face pulling the strings from the dugout might have a profound effect.