Matt Maiocco of NBC Sports Bay Area noted the 23-year-old will miss his first contest with injury since his freshman year of high school. He played three years at Georgia Southern before signing with the Niners as an undrafted free agent.
Breida was solid as a rookie in 2017 with 465 rushing yards, 180 receiving yards and three touchdowns. He also worked as a kick returner at times. The McKinnon injury presented the opportunity for the Florida native to be a featured back, and he responded with 138 rushing yards in the second game of the year against the Detroit Lions.
He has 744 rushing yards, 209 receiving yards and five touchdowns in 2018.
The 49ers will likely turn toward undrafted rookie Jeff Wilson again after doing so during the Seahawks loss. Wilson tallied 61 rushing yards and 73 receiving yards in his second game.