ESPN.com's Adam Schefter and Chris Mortensen reported on Monday morning that Sproles tore his ACL and broke his arm on the same play against the Giants. Schefter also reported Sproles will undergo surgery on his arm on Monday, with knee surgery coming at a later date.
Sproles has been healthy over the past couple of seasons, and he missed just one game in 2016 due to a concussion.
As a result, Sproles was able to rack up 865 yards—his highest total since the 2012 season—with four touchdowns from scrimmage in his first year under head coach Doug Pederson.
Entering Week 3, Sproles had rushed 12 times for 50 yards to go along with seven receptions for 73 yards. He has been unable to score a touchdown this season.
With LeGarrette Blount penciled in as the Eagles' early-down workhorse, second-year back Wendell Smallwood should be in line to pick up the slack on obvious passing downs in Week 4 against the Los Angeles Chargers.