The forward suffered the injury after Zaza Pachulia fell into his knee. He took only one shot in two minutes of game time before leaving the floor.
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The Warriors later announced he will have an MRI on his hyperextended left knee. Adrian Wojnarowski of The Vertical indicated Durant's injury could be serious:
"We'll just wait and see and keep our fingers crossed," Warriors head coach Steve Kerr told reporters after the game.
Durant is in his first season with the Warriors after famously picking Golden State over the Oklahoma City Thunder and others during free agency in the offseason. While many expected his numbers to drop on a loaded team, the forward has been nearly as good as ever with incredible efficiency.
Through 58 games, he is averaging 25.8 points and 8.4 rebounds per game with a 53.8 field-goal percentage that ranks as the best in his career.
His performance has helped the Warriors remain the top team in the Western Conference as the organization tries to bring home its second NBA title in three seasons.
This type of team success is just about the only thing missing from Durant's career. The 28-year-old has already earned eight All-Star nods in 10 seasons, been named first-team All-NBA five times and has one MVP award.
Even with plenty of offensive firepower on the roster that includes Stephen Curry and Klay Thompson, the Warriors will miss Durant for as long as he is unavailable. The team will still be able to score, but depth could be a concern at forward.
Andre Iguodala and rookie Patrick McCaw should get additional minutes on the wing in the immediate future.