This is another setback for Mathews, who suffered an MCL injury earlier in the season.
Durability has been a concern throughout his career, and he played just six games for the San Diego Chargers in 2014. He has played a full 16-game schedule just once (2013) since entering the league in 2010.
Mathews has shown flashes of impressive talent throughout his career and tallied 1,091 rushing yards in 2011 and 1,255 in 2013. He notched 539 yards on the ground last year in his first season with the Eagles, and his 5.1 yards per carry marked a career high.
He finishes the 2016 campaign with 661 yards and eight touchdowns on 155 carries.
Looking ahead, Darren Sproles is shifty in the open field and a two-way threat as a pass-catcher and runner, and he will likely see a lot more playing time after Mathews' injury. He's the top RB on the depth chart after a series of backfield injuries to Mathews, Wendell Smallwood and Kenjon Barner.
Byron Marshall, who has just nine carries so far during his rookie campaign, could also see his first extended action of the season in Week 17.