Liverpool vs. Manchester United is arguably the biggest rivalry in English football.
Liverpool have already been beaten twice by United this season, though both those victories came at Old Trafford.
The first of those matches was under the dreadful tenure under Roy Hodgson, where Liverpool were thwarted by a in-form Berbatov. The second time was the FA Cup tie, which was the Kenny Dalglish's first match in charge of the Reds, who, despite playing well, lost out to two questionable calls by Howard Webb.
The recent undefeated run under Kenny Dalglish's leadership was only broken last week in a 3-1 loss against West Ham.
Manchester United, themselves, had been a part of a great undefeated streak for over six months, which was ended by Wolves.
With a loss to Chelsea at Stamford Bridge on Tuesday and Arsenal close on their heels, United would not like to drop any points, especially with a crucial away tie at the Emirates still to play.
Neither of the teams should be at full strength as both are expected to have some key players missing due to injuries and suspensions.
Martin Kelly is certain to miss the match with Aurelio, Meireles and Agger all still doubtful to play due to injury.
Manchester United have their share of problems in the defense with Vidic suspended and injuries to Rio Ferdinand and Johnny Evans. Even Patrice Evra is doubtful for the clash.
United's last match at Anfield in 2009 saw Liverpool beating them 2-0 with goals from Torres and N'gog and red cards to Mascherano and Vidic.
With both Torres and Mascherano not with Liverpool anymore and N'gog not expected to start, Liverpool would need to look elsewhere for inspiration.
So, lets look at five key battles that could decide the outcome of the match.