College Football Picks Week 6: Predicting Five Big Blowouts

College football surprises its fans every week with upsets and ranking changes. However, sometimes college football will follow a week of stiff competition with a week of laughers. Some of this week’s top 25 match-ups are most likely to be over by the first quarter. Week 6 has all the biggest blowouts of the season.

5. Wyoming at No. 5 TCU

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DALLAS - SEPTEMBER 24: Quarterback Andy Dalton #14 of the TCU Horned Frogs at Gerald J. Ford Stadium on September 24, 2010 in Dallas, Texas. (Photo by Ronald Martinez/Getty Images)

TCU will win this game by a large margin. If TCU wants to raise eyebrows in the BCS, they will have to blowout all of their opponents this season, especially one’s like Wyoming. TCU’s quarterback, Andy Dalton, has a chance to explode during this game. He needs to regain the momentum he had last year if he wants to be a national championship contender. Saturday’s game will be played at TCU, giving them that much more of an edge.

4. Indiana at No. 2 Ohio State

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COLUMBUS, OH - SEPTEMBER 18: Terrelle Pryor #2 of the Ohio State Buckeyes runs with the ball against the Ohio Bobcats at Ohio Stadium on September 18, 2010 in Columbus, Ohio. (Photo by Jamie Sabau/Getty Images)

Indiana will fall quickly into the first half. Though Indiana is 3-1, they have not played any competitive football programs except for Michigan, which they lost to at home. Ohio State and their Heisman candidate, Terrelle Pryor, are playing at home this weekend against Indiana and if the game isn’t over by the first half, Ohio State must be off. If that happens, Pryor will just dominate with just his legs.

3. No. 22 Oklahoma State at Louisiana-Lafayette

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STILLWATER, OK - SEPTEMBER 5: Head coach Mark Richt of the Georgia Bulldogs congratulates head coach Mike Gundy of the Oklahoma State Cowboys after the Cowboys won the game 24-10 at Boone Pickens Stadium on September 5, 2009 in Stillwater, Oklahoma. (Pho

The Cowboys lead the series 5-0 against the Cajuns. Though a loss could drop Oklahoma State from their No. 22 spot, the pressure of the game shouldn’t be a faltering factor. The Cajuns were beaten 55-7 earlier in the season by Georgia, whom is no longer ranked. The cowboys are expected to put big numbers up on the board against the Cajuns this weekend and walk away with a huge win.

2. Toledo at No. 4 Boise State

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LANDOVER, MD - SEPTEMBER 06: Running back Jeremy Avery #27 of the Boise State Broncos carries the ball against the Virginia Tech Hokies at FedExField on September 6, 2010 in Landover, Maryland. (Photo by Geoff Burke/Getty Images)

If Boise State is serious about its national championship aspirations, the Broncos need to blowout all of their opponents. The Broncos will be playing at home Saturday night against Toledo. Boise State is a favorite to win by 39 points. Since their last loss at home was in 2001, the Broncos probably don’t want to break the streak with a team like Toledo. This game should be over within the first ten minutes.  

1. No. 3 Oregon at Washington State

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EUGENE, OR - OCTOBER 2: Head coach Chip Kelly of the Oregon Ducks is greeted by 'Puddles', the mascot of the Oregon Ducks, before the game against the Stanford Cardinal at Autzen Stadium on October 2, 2010 in Eugene, Oregon. Oregon won the game 52-31. (Ph

Oregon will destroy Washington State. Period. While Oregon puts up at least 42 points per game, Washington State gives up over 42 points per game. Heisman hopeful and Oregon Running Back, LaMichael James, will be able to add some big numbers to his resume this weekend when the Ducks slaughter Washington State. The Ducks are just a better team all around. The only way that Oregon will not blowout this team Saturday is if there is a freak hurricane that comes through and they have to reschedule to blow them out another day.