Per AJ Cassavell of MLB.com, five of the 12 Padres' position players are now out because of testing positive for COVID-19 or contact tracing.
Tucupita Marcano, who was called up from Triple-A El Paso on Tuesday following the news on Tatis, Profar and Mateo, replaced Myers in the lineup. John Andreoli, who was also placed on the Padres' roster Tuesday, took over for Hosmer.
As for the game, Manny Machado's five RBI paced the Padres, who improved to 20-16. The Rockies fell to 12-23.