The match against the Toffees will be the club's 4,000th in succession with a homegrown player in the squad. It's a run that dates back to 1937.
Pogba arrived at United's academy as a 16-year-old in 2009 and while he went on to join Juventus, he returned to Old Trafford in 2016, becoming the club's all-time record signing.
Pogba will not be involved in the clash on Sunday due to injury, but a number of other academy graduates will. Speaking to MUTV, the France international reflected on what he considers to be a remarkable achievement:
"It's unbelievable and it shows the identity of this club and the culture of this club. We've always talked about youth players coming into the first team and it's just carried on.
"It's something that is in this club, it's incredible it's been happening since 1937. You want to carry this on for the young players and the next generation to go and play in the first team."
As Sky Sports Premier League relayed, in the Red Devils squad for a 2-1 win over Manchester City on Saturday there were a number of players who were schooled in the United system:
In the current side, the biggest name to come out of the club's youth setup is arguably Marcus Rashford, with the forward excelling this season in a role from the left flank. The 22-year-old opened the scoring in the 2-1 win at the Etihad Stadium, calmly finishing from the penalty spot.
Per Sky Sports Statto, already the England international has matched his best-ever total of Premier League goals in a campaign:
As relayed by ESPN FC, at the same age, Rashford's goal return compares well to that of United icon and current Juventus forward Cristiano Ronaldo:
While the Red Devils have been among the biggest spenders in European football during the Premier League era, it's clear those at the top of the club feel a duty to ensure there's a pathway from the academy into the first team.
During his tenure, manager Ole Gunnar Solskjaer has got plenty wrong, but supporters will be encouraged by the opportunities he has given to rising stars and the belief he clearly has in them.
With United playing well, Pogba will be desperate to return from injury as quickly as possible, having not played since September. Solskjaer said on Friday that the France international won't be available for the showdown with Everton, but will be back in training again next week.