Barkley has missed the last three games due to an ankle injury, while Engram missed last week's contest against the New England Patriots with a knee injury.
Barkley suffered the injury on Sept. 22 and was later diagnosed with a high-ankle sprain. As he reached the three-week mark in the recovery process, he let everyone know last Sunday that he was nearing a return:
One day later, he returned to the practice field.
Though his status for Week 7 remained unclear, he told reporters on Thursday that he believes his ankle is capable of holding up through a game at this point.
"No doubt in my mind," Barkley said, per ESPN's Jordan Raanan. "I feel pretty good."
Despite having missed half of the season to this point, Barkley remains the Giants' leading rusher—and it's not close. He has 237 rushing yards, picking up 6.4 yards per carry, and one touchdown in three appearances this season. Third-year back Wayne Gallman has 107 yards and two touchdowns in five games.
Being sidelined has not been easy for Barkley, but his absence has taught the second-year star a valuable lesson, per Raanan:
"I guess you can say 'Angry Saquon,' but it's going to be more just appreciation, because when you actually get the game taken away from you—don't get me wrong, I know it's not a season-ending injury, it was an injury that took me out for a couple weeks, but when you're passionate about this game and when you have to step away from it and...can't really do much for your team, [it] makes you understand how much you actually care and appreciate this game.
"So it's going to be more a person who appreciates the game and just try to go out there and do whatever it takes to win for his teammates."
Meanwhile, Engram will look to pick up right where he left off. He leads the Giants in catches (33), receiving yards (373) and touchdown receptions (two).
"I made all my cuts, I moved around well," Engram said on Wednesday, per Madelyn Burke of Sports Illustrated. "... I've done a really good job of recovering and taking care of myself."
Engram has averaged 5.3 receptions and 69.7 yards in three games with rookie Daniel Jones under center.
33%, it's Week 7. The predictive models are humming, the stats are flowing, and the Sharp nuggets are plentiful this week. Why is Dalvin Cook going to absolutely explode for the rest of the season? Why are the Ravens a good bet to put up major points against the Seahawks? Why might the Dolphins actually win a few games...? Actually, let's not go too crazy with that last one. But as always, keep listening, and you'll hear Warren Sharp's exclusive discount for his incredible proprietary NFL information only for Lefkoe Show listeners. Happy gambling!