Reliever Pat Neshek, who was acquired from the Philadelphia Phillies on Wednesday, was activated to take Desmond's spot on the roster.
This is another setback for Desmond, who dealt with a calf injury earlier in the year and underwent surgery for a broken bone in his hand before the season. He didn't make his season debut until April 30 because of the hand issue.
The two-time All-Star and three-time Silver Slugger winner has batted .285 with a .328 on-base percentage, five home runs and 32 RBI in 2017 after slashing .285/.335/.446 with 22 home runs and 86 RBI last year as a member of the Texas Rangers.
When healthy, Desmond adds an additional source of power to the Rockies lineup, but they have enough pieces to survive his setback in the short term. The combination of Carlos Gonzalez, Gerardo Parra, Alexi Amarista and Pat Valaika can cover the corner outfield spots, while Mark Reynolds can play first base.
Still, Colorado could use a healthy Desmond in its lineup as it pursues a postseason spot for the first time since 2009.