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2025 Week 11 College Football Predictions for Every Game
At first glance, the Week 11 schedule might not appear all that dangerous.
Depending on your chosen poll, there's only two or three matchups between ranked teams. More than a handful of Top 25 programs have an open weekend, too. On paper, it should be a straightforward slate.
But you, a smart college football fan, know better than to believe that. There is always an upset looming around the corner.
BYU's trip to Texas Tech is the biggest game of the weekend. Texas A&M heads to Missouri for a critical SEC contest, and Oregon plays at Iowa in ever-dangerous Kinnick Stadium. The headliners are still excellent.
The major takeaways, though, may happen where we least expect—and every unanticipated result can rapidly upend the College Football Playoff race.
Rankings are based on the AP Top 25 due to publish time.
Click here for the latest college football game predictions.
Top Matchups for Week 11
1 of 5
Tulane (6-2) at No. 22 Memphis (8-1), Friday, 9 p.m. ET
The lingering question for Memphis is the health of quarterback Brendon Lewis, who exited the loss at UAB early and dealt with another issue at Rice last week. As long as he's available, Memphis should be able to outlast a flawed yet stingy Tulane team. Without him, though, it would be a major challenge.
Prediction: Memphis 29, Tulane 24
No. 8 BYU (8-0) at No. 9 Texas Tech (8-1), Noon
Although the competition level has been relatively low, Texas Tech has dominated at home so far. BYU, meanwhile, has needed to recover from a double-digit deficit in all three previous Big 12 road matchups. Texas Tech, in theory, will not be as forgiving because of its top-tier defense.
Prediction: Texas Tech 31, BYU 23
No. 3 Texas A&M (8-0) at No. 19 Missouri (6-2), 3:30 p.m.
Missouri is down to third-string QB Matt Zollers, a freshman with one game of 29 career pass attempts. Texas A&M's offense may struggle with a particularly motivated defense—one that understands it needs to shoulder a heavy burden here—but Mizzou hasn't forced multiple turnovers against any FBS opponent. To spring the upset, that streak probably needs to change.
Prediction: Texas A&M 27, Missouri 21
No. 6 Oregon (7-1) at Iowa (6-2), 3:30 p.m.
As usual, Iowa's passing game is nothing special. Don't expect a trend-busting day against an elite Oregon secondary, either. Iowa, however, has been phenomenal on defense all season, and a powerful rushing attack is finding its stride. If the Hawkeyes force Oregon to grind out long drives, an ugly game favors Iowa.
Prediction: Iowa 20, Oregon 19
LSU (5-3) at No. 4 Alabama (7-1), 7:30 p.m.
I don't have empirical data to defend this statement. But when a coach gets fired, it seems the interim often sparks a temporary surge. That feels like a real possibility for LSU, which looked uninspired as Brian Kelly's tenure ended. No, that's not enough to suggest a reeling LSU offense will suddenly overpower Bama on the road. LSU is certainly good enough to make it uncomfortable, though.
Prediction: Alabama 27, LSU 20
Weekday Games
2 of 5
Northwestern (5-3) at No. 20 USC (6-2), Friday, 9 p.m. ET
Despite not scoring more than 22 points against five Big Ten teams, Northwestern has managed three wins in those matchups. This is a stingy group. Unfortunately for the 'Cats, they're going to be challenged by a USC offense that has reached 31-plus points in every home game.
Prediction: USC 34, Northwestern 17
Kent State (3-5) at Ball State (3-5), Wednesday, 7 p.m.
Prediction: Ball State 27, Kent State 23
Northern Illinois (2-6) at Toledo (4-4), Wednesday, 7 p.m.
Prediction: Toledo 26, NIU 16
Georgia Southern (3-5) at Appalachian State (4-4), Thursday, 7:30 p.m.
Prediction: App State 30, Georgia Southern 28
UTSA (4-4) at South Florida (6-2), Thursday, 7:30 p.m.
Prediction: USF 41, UTSA 31
Houston (7-2) at UCF (4-4), Friday, 8 p.m.
Prediction: UCF 24, Houston 20
Saturday Early Games
3 of 5
No. 2 Indiana (9-0) at Penn State (3-5), Noon ET
Indiana hasn't yielded more than 20 points all season. This is simply an exceptional team. Penn State must be respected because of its defensive upside, but an offense that has mustered 3.5 yards per snap without Drew Allar is a problem.
Prediction: Indiana 34, Penn State 17
No. 5 Georgia (7-1) at Mississippi State (5-4), Noon
For the sake of not burying the lede, I'll take Georgia. I don't trust Mississippi State's defense to stop giving up 400-plus yards and 30-some points to SEC opponents. However, an up-and-down UGA defense cannot afford to have a slow day against Blake Shapen. He's quietly been a very efficient passer in 2025, and MSU only lost to both Tennessee and Texas by seven points at home.
Prediction: Georgia 33, Mississippi State 27
No. 1 Ohio State (8-0) at Purdue (2-7), 1 p.m.
Purdue stuck with Michigan in the Big House last weekend, so the Boilers should have a bit more confidence at home. Also, you won't find me saying Ohio State—which has allowed 6.9 points per game—will lose to Purdue.
Prediction: Ohio State 41, Purdue 10
The Citadel (4-5) at No. 7 Ole Miss (8-1), 1 p.m.
Clemson defeated The Citadel 51-14 last season, and that 37-point difference was the lower-division program's closest margin against an FBS opponent since 2020. No fancy analysis necessary here.
Prediction: Ole Miss 56, The Citadel 10
SMU (6-3) at Boston College (1-8), Noon
Prediction: SMU 31, Boston College 20
Colorado (3-6) at West Virginia (3-6), Noon
Prediction: WVU 34, Colorado 24
Temple (5-4) at Army (4-4), Noon
Prediction: Army 28, Temple 23
James Madison (7-1) at Marshall (4-4), Noon
Prediction: JMU 35, Marshall 21
Southern Miss (6-2) at Arkansas State (5-4), Noon
Prediction: Southern Miss 33, Arkansas State 27
Missouri State (5-3) at Liberty (4-4), 1 p.m.
Prediction: Liberty 30, Missouri State 26
Bowling Green (3-6) at Eastern Michigan (2-7), 1 p.m.
Prediction: EMU 24, BGSU 21
UAB (3-5) at Rice (4-5), 2 p.m.
Prediction: UAB 27, Rice 23
Maryland (4-4) at Rutgers (4-5), 2:30 p.m.
Prediction: Rutgers 31, Maryland 29
Charlotte (1-7) at East Carolina (5-3), 3 p.m.
Prediction: ECU 42, Charlotte 17
Tulsa (2-6) at Florida Atlantic (3-5), 3 p.m.
Prediction: FAU 37, Tulsa 31
Jacksonville State (5-3) at UTEP (2-6), 3 p.m.
Prediction: Jax State 27, UTEP 24
Louisiana Tech (5-3) at Delaware (4-4), 3 p.m.
Prediction: Delaware 28, Louisiana Tech 27
Florida International (3-5) at Middle Tennessee (1-7), 3 p.m.
Prediction: MTSU 26, FIU 23
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Saturday Afternoon Games
4 of 5
Syracuse (3-6) at No. 18 Miami (6-2), 3:30 p.m. ET
This is a test of focus for Miami, which squandered a brilliant start to the campaign with losses to Louisville and SMU. In all likelihood, the 'Canes are out of the CFP race. Can they bounce back to roll Syracuse, which has tallied no more than 18 points in a game since an injury ended quarterback Steve Angeli's season?
Prediction: Miami 38, Syracuse 21
Auburn (4-5) at No. 15 Vanderbilt (7-2), 4 p.m.
The major unknown about Auburn is how the offense changes after the school moved on from Hugh Freeze, who also called plays. I'm not straying from taking a Vanderbilt squad that is unbeaten at home, but that unpredictable post-firing bump has a clear way to impact Auburn this weekend.
Prediction: Vanderbilt 24, Auburn 19
No. 24 Washington (6-2) at Wisconsin (2-6), 4:30 p.m.
Wisconsin has scored 41 points in six games against power-conference foes, while Washington just put up 42 points on Illinois last weekend. Only a heroic defensive effort could save the Badgers, it seems.
Prediction: Washington 31, Wisconsin 10
Duke (5-3) at Connecticut (6-3), 3:30 p.m.
Prediction: Duke 38, UConn 31
Kansas (5-4) at Arizona (5-3), 3:30 p.m.
Prediction: Arizona 30, Kansas 27
Iowa State (5-4) at TCU (6-2), 3:30 p.m.
Prediction: TCU 36, Iowa State 24
Kennesaw State (6-2) at New Mexico State (3-5), 4 p.m.
Prediction: Kennesaw State 31, NMSU 24
Georgia State (1-7) at Coastal Carolina (5-3), 4 p.m.
Prediction: Coastal Carolina 33, Georgia State 23
Stanford (3-6) at North Carolina (3-5), 4:30 p.m.
Prediction: UNC 27, Stanford 17
Texas State (3-5) at Louisiana (3-6), 5 p.m.
Prediction: Louisiana 34, Texas State 30
Air Force (2-6) at San Jose State (3-5), 6 p.m.
Prediction: SJSU 35, Air Force 28
Saturday Evening and Late Slate
5 of 5
Wake Forest (5-3) at No. 12 Virginia (8-1), 7 p.m. ET
How many times can Virginia play with fire before it gets burned? It's a delicate act to survive on a weekly basis, but UVA continues to win thanks to timely defense. The timing of this matchup may also be ideal for UVA because Wake Forest has an unsettled QB situation that worsened in a blowout loss at Florida State.
Prediction: Virginia 27, Wake Forest 21
Cal (5-4) at No. 14 Louisville (7-1), 7 p.m.
Cal's total inability to run the ball is always a problem, but having no threat of a running game in this matchup is especially bad. Louisville has ceded just 5.7 yards per pass attempt and given up nine scores compared to 12 interceptions.
Prediction: Louisville 37, Cal 17
Navy (7-1) at No. 10 Notre Dame (6-2), 7:30 p.m.
Notre Dame stumbled through the first half at Boston College but still pulled away late. If the Fighting Irish have a slow start defensively, Navy can keep it close into halftime, too. Eventually, though, ND's talent will prevail.
Prediction: Notre Dame 42, Navy 20
Florida State (4-4) at Clemson (3-5), 7 p.m.
Prediction: Clemson 31, Florida State 28
Florida (3-5) at Kentucky (3-5), 7:30 p.m.
Prediction: Florida 26, Kentucky 17
Nevada (1-7) at Utah State (4-4), 7:30 p.m.
Prediction: Utah State 35, Nevada 24
Nebraska (6-3) at UCLA (3-5), 9 p.m.
Prediction: UCLA 23, Nebraska 20
UNLV (6-2) at Colorado State (2-6), 9:30 p.m.
Prediction: UNLV 34, CSU 27
Sam Houston (0-8) at Oregon State (2-7), 10 p.m.
Prediction: Oregon State 38, Sam Houston 14
San Diego State (7-1) at Hawaii (6-3), 11 p.m.
Prediction: Hawaii 27, SDSU 24
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