NFL Week Three Spreads and Picks: Vikings-49ers, Lions-Redskins, Bears-Seahawks

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NFL Betting—Week Three Picks

NFL Week Three matchups are here already. Hard to believe how quickly the season is going. We’ve already seen a massive upset happen—how about those Bengals over the Packers?—and there could be an even bigger one on the horizon this weekend. Let’s make a few NFL picks.

San Francisco 49ers at Minnesota Vikings

Sunday, Sept. 27, 1 p.m. ET

NFL betting favorite: Vikings -6.5

Here’s our chance to find out if San Francisco is truly for real. Frank Gore destroyed Seattle’s defense last week, racking up 207 rushing yards, but he faces the formidable Minnesota run defense led by Pat and Kevin Williams this week. If (when?) the Vikes stack the box and bottle up Gore, Shaun Hill will have to do more than caretake from the quarterback position. I’m not so sure he’s up to the task. San Fran’s “D” looks excellent under Mike Singletary but hasn’t faced a tailback anywhere close to Adrian Peterson’s caliber so far. Bet on Minnesota to cover.

Betting services recommend: Vikings -6.5

Washington Redskins at Detroit Lions

Sunday, Sept. 27, 1 p.m. ET

NFL betting favorite: Redskins -6

Here’s your big shocker of the week. The Redskins are a superior team, of course, but they’re out of sorts. When you only beat the Rams 9-7 at home and score no touchdowns, how can you be a safe six-point favorite on the road against any team? Washington is struggling to pressure the quarterback, recording just two sacks in two games even after a matchup against Marc Bulger. That means Matt Stafford may have time to unleash some big throws to Calvin Johnson. The Lions can at least beat the spread and have a real shot to win outright.

Betting services recommend: Lions +6

Chicago Bears at Seattle Seahawks

Sunday, Sept. 27, 4:15 p.m. ET

NFL betting favorite: Bears -1.5

After Matt Hasselbeck went down last week and Frank Gore trucked the Seahawks’ front seven, it’s a bit surprising that the Bears are only 1.5-point favorites. You’d think they’d be more popular choices after beating the defending Super Bowl champion Steelers. Jay Cutler found a groove against the Steelers and Matt Forte is itching to bust out. If Hasselbeck plays, he’ll still likely be ineffective playing through a broken rib. If he doesn’t, the Bears could rout the Seahawks.

Betting services recommend: Bears 1-.5