MLB Playoff Picture: Boston Red Sox SP Jon Lester Has Never Lost to the Orioles

The Boston Red Sox would complete the biggest Major League Baseball collapse in history if they happen to drop Wednesday night's contest against the Baltimore Orioles.

Baseball fans can watch it unfold on ESPN with the first pitch scheduled for 7:05 p.m. ET inside Orioles Park at Camden Yards.

Simply put, there's not another pitcher on the planet that the franchise would want on the mound other than Jon Lester in the final game of the regular season.

The left-hander is a sensational 14-0 with a 2.33 ERA in 17 career starts versus the Orioles, including an unblemished 7-0 record and 2.47 ERA in nine appearances at Camden Yards.

His mark is the longest win streak by any active pitcher versus any team in the league—simply dominating numbers.

That's why a loss in this situation would complete the biggest fallout in baseball history.

The odds makers have placed an extremely high tariff on a team that has compiled a 7-19 record in September, sending out the Boston Red Sox as minus-220 road favorites.

It's likely going to do the trick, as the club is 23-3 in Lester's last 26 starts when favored by minus-200 or greater, but the club is 1-4 in its last five games when laying juice away from Fenway Park.

His opposition Wednesday night is reliever-turned-starter Alfredo Simon, who is 4-9 with a 4.85 ERA in 22 appearances (15 starts) this season.

The Dominican Republic native has yet to record a victory against the Red Sox in seven relief appearances (one start) versus the Red Sox, going 0-1 with a 5.59 ERA.

Boston fans are expecting a win, but the team's plane is likely headed to Tampa Bay for a one-game playoff Thursday afternoon.