O'Neil also served as co-host of the second night of last year's WrestleMania alongside NFL star Rob Gronkowski.
Mania hosts appear sporadically throughout professional wrestling's marquee event, which has taken place over two days instead of a single night over the last two years amid the coronavirus pandemic.
Hogan is one of the most well-known wrestlers in history with a career that dates back to the late 1970s. He reached his peak of popularity from the late 1980s through the late 1990s, a decade-long run of Hulkamania that made him a household name that transcended WWE.
He appeared in eight WrestleMania main events during his career, highlighted by his battle with Andre the Giant at WrestleMania III that helped the Showcase of the Immortals become a cultural phenomenon.
His clash with The Rock at WrestleMania 18 in 2002 wasn't the main event, but it was a hallmark match that helped usher in a new era of Superstars to carry WWE.
In 2015, WWE terminated its contract with Hogan following the release of a video in which Hogan repeatedly made racist remarks regarding the possibility of his daughter dating someone who is Black. Hogan would return to the company in late 2018.
Hogan is a two-time inductee in the WWE Hall of Fame, entering as an individual in 2005 and as part of the NWO in 2020. The 2020 class will be formally inducted during this year's WrestleMania week since the ceremony was canceled last year because of the pandemic.
Meanwhile, O'Neil is an active member of the WWE roster, but he's rarely appeared on television over the past few years while focused on his Bullard Family Foundation and his work as a WWE brand ambassador. He also authored his first book in 2019.
The former University of Florida college football player posted on Twitter he's "honored, excited and humbled" to serve as a WrestleMania host in his hometown:
Titus O'Neil @TitusONeilWWE
I’m Honored, Excited and Humbled to be Hosting @WrestleMania this year in my HOMETOWN @CityofTampa at @RJStadium tickets are on sale Now for this 2 Night Sports Entertainment Spectacle that is Globally known as the “Grandest Stage of Them All” #WrestleMania aka #TitusMania 😎 https://t.co/tyyFUlLpZr
Hogan and O'Neil will kick off the Show of Shows on April 10 with a card expected to feature numerous high-profile matches, including Roman Reigns vs. Edge, Sasha Banks vs. Bianca Belair and Bobby Lashley vs. Drew McIntyre.
The rest of the card should come into focus in the coming weeks following Sunday's Fastlane pay-per-view.