Ian Rapoport of NFL Network reported Sunday the Cardinals are planning to assess their "entire football operation" following the season.
Wilks' first year in Arizona has been a disappointment, with the Cardinals 2-9 and looking uninspired on both sides of the ball. Rookie quarterback Josh Rosen has struggled to impress, and the Cardinals offense is averaging more than 40 fewer yards per game than any other team.
"Definitely was embarrassing, definitely not what we want," Wilks told reporters following the Cardinals' 45-10 loss to the Los Angeles Chargers last week. "This organization, that team in that locker room, those players and coaches, we got to do better."
Arizona has been outscored by 138 points this season, the second-worst differential in football behind the Oakland Raiders (140).
Wilks replaced Bruce Arians in Arizona after one year as the Carolina Panthers' defensive coordinator. He had served as an NFL defensive assistant since 2005.
The Cardinals in October fired offensive coordinator Mike McCoy and replaced him with Byron Leftwich. The team has not fared much better in four games under Leftwich, averaging 15.8 points per game. McCoy's unit had recorded 13.1 points per game.
It's possible Wilks will have to revamp his coaching staff in order to keep his job.