The Tigers placed Martinez on the 10-day disabled list on Aug. 27 with an irregular heartbeat, which marked the second time this season he landed on the DL with that ailment. Detroit transferred Martinez to the 60-day disabled list on Sunday.
The 38-year-old veteran has struggled even when healthy in 2017, hitting .255 with 10 home runs and 47 RBI in 107 games.
Those home run and RBI totals mark his lowest in a single season since he appeared in just 73 games for the Cleveland Indians in 2008.
Last year, the five-time All-Star turned in a productive campaign, with a .289 batting average, 27 homers and 86 RBI.
V-Mart's poor showing has been a microcosm of the Tigers as a whole, as Detroit entered play Sunday with a record of 58-77, tied for second-worst in the American League.
The Tigers on Thursday traded left fielder Justin Upton and starting pitcher Justin Verlander, and Martinez's absence will provide the team with another opportunity to utilize younger players to prepare for the future.
It is unclear how Martinez's heart procedure will impact his career moving forward, but he is under contract for one more year, per Spotrac.
In 15 seasons, Martinez is a .298 hitter with 237 home runs and 1,124 RBI.