The 27-year-old All-Star found out about the Canadian cover in the middle of the regular season and was blown away.
"I remember being a kid, creating a player in the video game, and being excited just doing that," DeRozan told theScore's Joseph Casciaro. "The next thing was being in the college basketball game, and then the next thing, being in the NBA game. Seeing your face, seeing yourself evolve in the game, and looking even more real, to hearing your voice in the game, to now, being on the cover. It's something that's extremely awesome and definitely mind-blowing."
DeRozan averaged a career-high 27.3 points in 2016-17, leading Toronto to the playoffs for the fourth straight season.
The game will hit stores September 19.