College Football Picks Week 6: Predictions and Odds for Top 25 Schedule

Don't get too attached to the latest college football rankings. Several ranked opponents will collide during an eventful Week 6 that is sure to affect the polls.

A dozen of the Top 25 schools will compete against a fellow ranked squad. Many of those marquee matchups include College Football Playoff contenders that can't afford a loss during their quest to solidify Top 4 placement.

October will begin in lavish style with this loaded slate of must-see TV. Last week consisted of many big-name schools fending off upsets, but some big boys are going down for real this weekend. That's not really going out of a limb considering two teams can't walk away from the same game with a victory.

Away	Home	Odds	Prediction
Wake Forest	No. 1 Florida State	FSU -38	42-20 FSU
Arizona	No. 2 Oregon	ORE -22.5	48-17 ORE
No. 3 Alabama	No. 11 Ole Miss	ALA -4.5	24-20 ALA
No. 4 Oklahoma	No. 25 TCU	OKL -17	30-21 OKL
No. 15 LSU	No. 5 Auburn	AUB -9	27-24 LSU
No. 6 Texas A&M	No. 12 Mississippi State	A&M -1	45-42 MISS
No. 7 Baylor	Texas	BAY -13	50-17 BAY
Utah	No. 8 UCLA	UCLA -12.5	38-14 UCLA
No. 14 Stanford	No. 9 Notre Dame	Even	13-10 STA
No. 19 Nebraska	No. 10 Michigan State	MSU -8	31-23 MSU
Vanderbilt	No. 13 Georgia	GEO -32.5	49-7 GEO
Arizona State	No. 16 USC	USC -7.5	37-17 USC
No. 17 Wisconsin	Northwestern	WIS -9.5	35-14 WIS
Utah State	No. 18 BYU	N/A	52-13 BYU
No. 20 Ohio State	Maryland	N/A	34-30 OSU
Iowa State	No. 21 Oklahoma State	OKU -17	45-10 OKU
SMU	No. 22 East Carolina	ECU -33.5	37-7 ECU
Texas Tech	No. 23 Kansas State	N/A	41-21 KSU

Game of the Week: No. 6 Texas A&M vs. No. 12 Mississippi State

With so many incredible games on the docket, picking the most intriguing clash is a nearly impossible task. Yet given recent developments from the past two weeks, the SEC clash between the undefeated Texas A&M Aggies and Mississippi State Bulldogs bears major implications.

Texas A&M nearly muddled this match's significance in a Saturday scare against Arkansas, entering the fourth quarter down 28-14. Kenny Hill then delivered two deep bombs to send the game into overtime, where he won the game with a 25-yard touchdown pass to Malcome Kennedy.

"We just made the connection on that one," Hill told The Associated Press, via Fox Sports, regarding the game-winning pass. "They had the defender getting there late, and I threw it to him. He took care of the rest."

After a rocky start, Hill dominated down the closing stretch, as illustrated by ESPN's College GameDay:

Despite the near-loss, the Aggies are 5-0 with a 24-point victory against South Carolina under their belt. This weekend marks the beginning of a brutal stretch for them that could make the Aggies a CFP contender if they can somehow escape the period with limited damage.

Not considered much of a threat entering the season, Mississippi State put the SEC on notice by upsetting LSU on Sept. 20. The Dak Prescott bandwagon reached full capacity after the team tallied 268 yards, 105 rushing yards and a touchdown each way during the monumental win at Baton Rouge.

ESPN Stats & Info put the stunner into perspective.

What will happen when two Heisman contenders clash to maintain their teams' unblemished record? Either way, a highly entertaining game with plenty of points is in order.

While the Aggies' defense has progressed this year, they've mostly beat up on inferior competition. Against South Carolina and Arkansas, they allowed 917 combined yards. They've padded their numbers against Lamar, Rice and SMU, but they haven't improved enough to contain Prescott.

Hill will also get his points, so this matchup could very well boil down to who gets the ball last or which side makes the biggest mistake at the most inopportune time.

In his last three games, Prescott has registered at least 200 passing yards and 100 rushing yards each time with 10 total touchdowns. Texas A&M isn't built to stop him, so the rising junior will shake up the SEC landscape by once again knocking off a higher-ranked conference adversary.

Prediction: Mississippi State 45, Texas A&M 42