Can the Cardinals avoid the Super Bowl loser hangover that has happened consistently this decade (seven of eight teams that lost the Super Bowl missed the playoffs the year, except the 2006 Seahawks)?
Now that Edgerrin James has left town, will rookie Beanie Wells or second-year player Tim Hightower be the Cardinals featured running back and how many carries a game will they get?
How will new coordinators Russ Grimm and Bill Davis do at leading their respective units after both former coordinators left town for the Kansas City Chiefs after the Super Bowl?
Will Bill Davis’ defensive unit, particularly his secondary, improve on the 426 points that they allowed in 2008?
After receiving his two-year, $24 million contract, does quarterback Kurt Warner have another big season in him at almost age 40?
Who will the Niners starting quarterback be (Alex Smith, Shaun Hill, or Damon Huard) and are any of them capable of leading the team to the playoffs?
Was last year’s season-ending 5-2 push led by new Head Coach Mike Singletary proof that the Niners have turned the corner back to respectability?
Given the tough demeanor of Singletary, do you think his message will sink in with young players like tight end Vernon Davis, WR Michael Crabtree, and others?
When will WR Michael Crabtree sign with the Niners and will the heralded rookie from Texas Tech have a Marques Colston-type rookie year (led team in receptions and had over 1,000 yards receiving)?
Will the addition of players like veteran DB Dre Bly and three new defensive rookies from the draft help defensive coordinator Greg Manusky’s unit improve upon their sack (30 in ’08) and points allowed (381) numbers?
How healthy is quarterback Matt Hasselbeck (back) and will he be able to return to his 2005 Super Bowl form?
What will be the overall impact of new head coach Jim Mora Jr and his staff taking over from Mike Holmgren?
Are the Seahawks really going to spread carries between TJ Duckett, Julius Jones, and Justin Forsett or will one of the backs emerge as the featured ball carrier?
How healthy is DE Patrick Kerney and can Mora and defensive coordinator Gus Bradley breathe new life into the Seahawks defense?
What will the addition of former Bengals receiver TJ Houshmandzadeh mean to the Seahawks receiving core and are holdovers Nate Burrelson and Deion Branch healthy?
St. Louis Rams
How will the hiring of former Giants defensive coordinator Steve Spagnuolo change the culture of a Rams team that has not had a winning season since 2003?
After not playing to expectations from a huge contract, does quarterback Marc Bulger still have enough to be a quality starting quarterback in the NFL?
After barely gaining 1,000 yards in 2008 is running back Steven Jackson ready for a comeback season?
With receiver Torry Holt moving on to the Jaguars which receiver out of veteran Ronald Curry and youngsters Donald Avery and Laurent will become the Rams featured receiver?
What is going on with the Rams ownership group and is it possible that current owner Chip Rosenbloom will sell and/or relocate the team?
Lloyd Vance is a Sr. NFL Writer for Taking It to the House and an award winning member of the Pro Football Writers of America (PFWA)