NFL Picks Week 3: Which Teams Should Be on Upset Alert?

NFL fans love upsets, and every week we get a handful of games that don't go the way many predict.

Here are the best possibilities for an upset in Week 3 of the NFL season (not in order of probability):

New England Patriots (2-0) at Bills (2-0); Patriots 8.5-point favorites

Despite the Bills being 2-0, the Patriots are two-score favorites on the road. That's more of a statement about the Patriots than the Bills.

Tom Brady is playing on a different level to the rest of the league. Can the Bills really snap their 15-game losing streak to New England with Brady playing this well?

The Bills need Ryan Fitzpatrick to continue leading an efficient offense, especially in the red zone, while Buffalo's defense must keep the game in firing range in the fourth quarter.

New York Jets (2-0) at Oakland Raiders (1-1); Jets 3.5-point favorites

This is going to be a tougher matchup for the Jets than most casual fans think, and that's shown in the 3.5-point edge that betters have given this game.

After a long trip west, the Jets take on a team that should be 2-0. The visitors are also without Nick Mangold, their best offensive lineman and the best center in the game. If the Jets can't run the football, can Mark Sanchez win this game on his own? 

Green Bay Packers (2-0) at Chicago Bears (1-1); Packers 3.5-point favorites

The Bears have always played the Packers offense tough, so I wouldn't expect a high-scoring affair.

This game rides on the shoulders of Jay Cutler. Green Bay's defense has shown flashes of pressure this season, but it hasn't been consistent. They need to be on Sunday, especially with Nick Collins done for the season.

Matt Forte will also have a big say in whether the Bears can knock the Packers off the 2-0 perch for the second year in a row. 

Washington Redskins (2-0) at Dallas Cowboys (1-1); Cowboys 5.0-point favorites

I found it surprising that the Redskins were five-point underdogs on the road.

Washington's defense has looked completely the opposite of the bottom-ranked unit they were a season ago, and Rex Grossman has been good enough to win games.

The Cowboys defense also looks good, but they are banged up across the board. I think the Redskins could go into Dallas and leave with a win on Monday night. 

Atlanta Falcons (1-1) at Tampa Bay Buccaneers (1-1); Bucs 1.5-point favorites

This game is more or less a toss-up, betting-wise, but I like what I've seen from the Falcons more than the Bucs.

Both teams could realistically be 0-2 after having to come back from big deficits in Week 2. If Matt Ryan and the offense can avoid turnovers, the Falcons should be plenty capable of pulling off this upset.

Miami Dolphins (0-2) at Cleveland Browns (1-1); Browns 2.5-point favorites

The Dolphins have lost 11 of their last 12 games at home, so they welcome a road game in Cleveland.

As long as the visitors get some pressure on Colt McCoy, the secondary shouldn't be in as much trouble as it has been in recent weeks. Chad Henne and the Dolphins offense can score on that Browns defense. 

New York Giants (1-1) at Philadelphia Eagles (1-1); Eagles 8.0-point favorites

Playing at home gives the Eagles an edge, but an 8.0-point edge? That's pushing it, for an NFC East rivalry game, especially with Michael Vick recovering from a concussion.

The Giants can pressure the quarterback with their front four, and that's what can get to Vick and the Eagles' offense.

If he gets hit early on in this game, there's no way the Eagles win by more than eight.