Irving has dealt with groin issues at various points this season. He sat out Brooklyn's previous meeting with the Pacers on March 17 with the same problem.
The Nets have had to take to the court without the seven-time All-Star several times this season. The team announced he wouldn't join them for a three-game road swing in March in order to deal with "a family matter."
Irving also missed seven games for personal reasons over a nine-day stretch in January. He played in each of the Nets' past nine games, but he was held to a season-low nine points on 3-of-13 shooting in Tuesday's 116-103 win over the Toronto Raptors.
Overall, the 29-year-old has missed 16 of the Nets' 62 games so far this season, not including Thursday. But when he is in the lineup, he is a strong piece of a dominant Nets team. He's averaging 26.9 points on 50.3 percent shooting with 6.4 assists and 5.0 rebounds this season.
Head coach Steve Nash will turn to Bruce Brown as his primary point guard until Irving can return.