The annual Skills Challenge pits players in one-one-one matchups where they race through identical courses and are required to dribble through obstacles, complete a pass into a net, run the length of the court to make a layup and run to the opposite end and make a three-point shot.
Boston Celtics star Jayson Tatum is the defending champion in the event.
Rose spent the first eight years of his career with the Chicago Bulls, who drafted him No. 1 overall in 2008. He quickly became their franchise cornerstone, winning Rookie of the Year and being named the youngest MVP in NBA history at age 22 during the 2010-11 season.
A series of injuries starting in the 2011-12 campaign knocked Rose's career off its upward trajectory. He hasn't played more than 66 games in a season since his MVP year.
Last season with the Minnesota Timberwolves was a bounce-back campaign for Rose. The 31-year-old only played in 51 games, but he averaged 18.0 points per contest and shot a career-high 37 percent from three-point range.
Rose joined the Pistons over the summer and has been one of their best offensive players with 17.3 points and a team-high 5.7 assists per game. His 48.6 shooting percentage is on pace to be the second-highest of his career (48.9 percent in 2009-10).