The team announced Tuesday the veteran will undergo surgery to heal a hip injury that has "plagued him since the offseason." He will be placed on injured reserve to end his season.
Crawford missed Weeks 3 and 4 with the injury before returning for the last two games. He saw limited action off the bench after starting the first two games of the season.
The 29-year-old had been a reliable player for the Cowboys since entering the league in 2012. From 2014-18, he appeared in 76 of 80 regular-season games for the team, starting 74 of them.
Crawford also set a career high with 5.5 sacks last season.
Adding his production with the ability to line up at both tackle and end, he was a valuable part of the Cowboys defense.
Fellow defensive lineman DeMarcus Lawrence gave his thoughts on the injury:
Antwaun Woods should see more playing time at defensive tackle with Crawford unavailable, but it's another problem for a Cowboys squad that has lost three straight games to fall to 3-3 on the season.