Sanchez has been at United for 16 months but has experienced a crash in form, suffering repeated injuries.
Inter Milan are reportedly exploring an opportunity to take Sanchez on a 12-month loan, with United having to pay half of the attacker's £500,000-per-week wages.
It has been a miserable spell for the Chile international after previously being one of the most dangerous players in the Premier League.
United's squad has experienced a collective failing in the past year, facilitating the end of Jose Mourinho's tenure in Manchester.
Former United defender Patrice Evra has questioned why Sanchez opted to sign for the Red Devils. Speaking to Sky Sports, the ex-France international said the player's motives might have been financial over football:
"Some players only come for the money, I am not afraid to say that.
"I have nothing against him, but Sanchez, when I saw the deal, that's when I thought the Manchester United history just went down.
"He had Manchester City, they were offering less money but he was going to play better football than United - I'm sorry about that, but City play better football and Guardiola will improve him.
"So I want to know what is the real reason for choosing United? Don't tell me he loved Manchester United when he was a kid.
"It's either the money or he wanted to be the number one, take the No. 7 shirt and be the star."
ESPN FC's Alex Shaw emphasised just how poor he thinks Sanchez has been since departing the capital:
Former United captain Gary Neville told Sky Sports it's a mystery why Sanchez has been such a flop:
Sky Sports Premier League @SkySportsPL
🔮 - "It's an absolute mystery...nobody can put any science or sense behind what has happened to him." Alexis Sanchez starts for @ManUtd today, but @GNev2 outlines the fact that everyone is still waiting for him to "turn up". Watch live @premierleague build-up on SSPL now! https://t.co/OgqyB460la
A number of first-team players are running out of time at United, and after ending the Premier League season in a disappointing sixth, the club needs to look elsewhere.
Sanchez was brought in to replace the world-class finishing of Zlatan Ibrahimovic, but he has only provided mediocrity and disappointment.
The high-octane game played by the forward appears to have stunted his career. Sanchez's age appears to have caught up with him despite only turning 30 in December.
The pace of English football is too much for the former Gunner, and a switch to Serie A could help boost his flagging reputation.