The match comes after a summer that has seen Cristiano Ronaldo swap Real Madrid for Juventus. The Portuguese star is not part of his new club's U.S. tour because of his 2018 FIFA World Cup exploits.
Juventus are slightly ahead of Real Madrid in their pre-season preparations. The game represents their final friendly before they open up their title defence at Chievo on August 18.
Massimiliano Allegri's side began with a 2-0 win over Bayern Munich. They then needed penalties to beat Benfica after a 1-1 draw.
Real Madrid go into the game after losing 2-1 to Manchester United. After taking on Juventus, they will conclude their campaign against Roma on Tuesday.
Date: Saturday, August 4
Time: 6:05 p.m. ET/23:05 p.m. BST
Venue: FedExField, Landover, Maryland
TV Info: Premier Sports 1 (UK), ESPN 2 (U.S.)
Real Madrid manager Julen Lopetegui is likely to pick a stronger team to the one that started against Manchester United.
Keylor Navas, Dani Carvajal, Isco and Toni Kroos could all start as the Spanish giants look to step up their preparations for the new season.
Lopetegui will also want more from Gareth Bale after he made little impression against the Red Devils. The Real Madrid boss said the Wales international can make up for Ronaldo's loss:
Isco is another player who could be set for a key role under Lopetegui. The 26-year-old has spoken about how important Lopetegui has been during his career, as Omnisport showed:
The Spain international's versatility and skill on the ball make him a dangerous opponent. He was one of La Roja's brighter performers at the World Cup and could cause Juventus all sorts of problems.
The Old Lady have yet to taste defeat at the International Champions Cup, but this game looks to be their toughest test.
Allegri's side have had an eventful summer beyond Ronaldo's arrival. They have also seen Leonardo Bonucci return from AC Milan, with striker Gonzalo Higuain going the other way on loan. Defender Mattia Caldara also joined the Rossoneri.
One of the stars of their U.S. tour has been 21-year-old striker Andrea Favilli, who has three goals in two games. However, his future lies away from Turin, according to football writer David Amoyal:
Juventus are without many of their key attackers for their pre-season tour. Douglas Costa, Paulo Dybala and Mario Mandzukic are all absent, but they can look to playmaker Miralem Pjanic for inspiration.
The 28-year-old has been showing off his skills during the tour, as Juventus showed:
With two games completed, Juventus may be the sharper of the two teams. The club's transfer activity this summer suggests their priority is to take Real Madrid's UEFA Champions League crown next season, and a win on Saturday would serve notice of their intent.