Per MailOnline's Charles Sale, the news was confirmed on Wednesday. Wilkins had been placed in an induced coma after being admitted to St George's Hospital in Tooting, London, last week following a cardiac arrest.
Wilkins was capped 84 times by England, captaining the team on 10 occasions, and represented his country at two World Cups. His 24-year senior club career also included spells with AC Milan and Rangers as well as two stints with Queens Park Rangers.
The PFA paid tribute to the Hillingdon-born midfielder on Twitter, as did a number of his former clubs:
His former England team-mate Gary Lineker also marked Wilkins' passing:
After retiring from playing in 199,7 Wilkins turned his hand to coaching. He enjoyed notable success as an assistant manager at Chelsea, winning the Premier League and FA Cup in the 2009-10 season.
His last position was as Tim Sherwood's No. 2 at Aston Villa in 2015.
Wilkins is survived by his wife, Jackie, and their two children, Ross and Jade.