According to ESPN.com's Eddie Matz, the Nationals became the sixth team in league history to smack five homers in an inning.
The power-packed frame also saw the Nationals hit four straight home runs, when Brian Goodwin, Wilmer Difo, Bryce Harper and Ryan Zimmerman went back-to-back-to-back-to-back before Anthony Rendon connected on a solo dinger later in the inning.
The Nationals seized a 9-0 lead by the time the third inning ended, and they didn't stop there.
After Bryce Harper doubled to left to score Difo in the fourth, Zimmerman stepped to the plate and connected on his second home run of the game. Jose Lobaton also got in on the party in the fourth with a 424-foot blast.
All told, Harper finished 3-for-5 with four RBI, while Zimmerman plated three runs on a day when the Nationals burned the Brewers for 19 hits.
"What a team we have," Harper said, according to the Washington Post's Chelsea Janes. "What a lineup we have."
Washington will aim to keep the runs flowing Friday when it opens a three-game set against the Colorado Rockies at Nationals Park.