The news comes after Whiteside was held out of Wednesday's game against the New York Knicks due to what was then described as left knee soreness.
In his sixth NBA season, Whiteside has become the Heat franchise's cornerstone. He's averaging 14.9 points, 12.7 rebounds and 1.6 blocks per game, co-starring with Goran Dragic on a team that's currently 10-11.
Whiteside missed five total games in 2016-17, all coming in January. He missed four at the beginning of the year with an eye injury and then one more later in the month with an ankle issue.
Kelly Olynyk and Bam Adebayo will most likely get extended minutes at the 5 with Whiteside out.