Hyde has been out since suffering a stress fracture in a Week 7 loss to the Seattle Seahawks.
The second-year running back got off to a great start on Monday Night Football in Week 1, rushing for 168 yards and two touchdowns in a 20-3 victory against the Minnesota Vikings.
He never broke 100 yards in the next six games, though, and scored just one touchdown. The 49ers have struggled to replace him, using a myriad of backups. Former starting quarterback Colin Kaepernick is second on the team with 256 rushing yards.
The team gave former rugby star Jarryd Hayne a chance at running back but eventually cut him.
The 49ers signed veteran Shaun Draughn midseason, but he's averaged just 3.3 yards per carry. However, as Chris Biderman of Niners Digest pointed out, Draughn has outperformed Hyde in total yards because of his pass-catching ability:
Yet quarterback Blaine Gabbert led the team with 75 rushing yards in a Week 13 win over the Chicago Bears, and as a team, the Niners rank 20th the league in rushing yards with 1,189.