It was a homecoming of sorts for new head coach Jim Tomsula, who faced off against his boyhood favorite team. But for the 49ers, the contest provided yet another opportunity for them to demonstrate their prowess despite all the offseason changes.
San Francisco was dealing with a short week after debuting on Monday Night Football in Week 1, while Pittsburgh was coming off an extended break after opening up the season on September 10.
The lack of time off worked against the 49ers as a series of miscues and sloppy play haunted San Francisco's efforts in the first half.
The 49ers looked to halt quarterback Ben Roethlisberger and all his offensive prowess while getting their own offense against a questionable Steelers defense.
Yet it was the Steelers who got their offense rolling. And their defense was equally as impressive to start.
Pittsburgh got on the board first with a two-yard touchdown reception from tight end Heath Miller, which was followed by a successful two-point conversion by wide receiver Antonio Brown.
San Francisco answered back with a 47-yard field goal from kicker Phil Dawson.
Brown continued to haunt the 49ers on the subsequent Steelers drive—setting up a two-yard DeAngelo Williams touchdown run after Brown hauled in a 59-yard pass from Roethlisberger. A subsequent two-point conversion succeeded.
With the 49ers offense struggling, Pittsburgh struck back quickly with a perfectly executed play-action pass from Roethlisberger to wide receiver Darrius Heyward-Bey. Running back Carlos Hyde fumbled on the 49ers' subsequent drive, which led to yet another Steelers touchdown from Williams.
The first half was a complete disaster for San Francisco.
The 49ers didn't get much help from their receivers in the third quarter. Drops from wide receiver Anquan Boldin and tight end Vernon Davis didn't help. But a dropped end-zone pass to fullback Bruce Miller negated a would-be touchdown for San Francisco.
San Francisco did wind up getting a touchdown to start the fourth quarter. Quarterback Colin Kaepernick found wide receiver Anquan Boldin for a 14-yard touchdown score.
But the Steelers answered right back with Williams' third touchdown rush.
Yet San Francisco finally exploited Pittsburgh's weak secondary with a deep 75-yard passing touchdown to wide receiver Torrey Smith who burned through the Steelers' defensive backfield.
Pittsburgh didn't seem to mind though. Brown continued to torch San Francisco's collapsing secondary with his first touchdown reception of the game.
And that would sum up San Francisco's efforts as the team drops to 1-1 on the young season.
Stay tuned right here for continuous scoring updates, analysis and insight throughout the game.
FINAL: 49ers 18, Steelers 43
Peter Panacy is a featured columnist covering the San Francisco 49ers for Bleacher Report. Follow him @PeterPanacy on Twitter.