USC vs. Arizona: Score and Twitter Reaction

Just one week after pulling a major upset win over the Oregon Ducks, the No. 10 Arizona Wildcats were bit by the upset bug themselves. On Saturday, the USC Trojans came into Tucson, Arizona, and handed the Wildcats their first setback of the season.

The 28-26 loss will almost certainly send the Wildcats tumbling in the polls.

"

Arizona falls to USC making it 4 teams this week to suffer a 1st loss.The only undefeated FBS teams left are... pic.twitter.com/PxgqpJ8QaH

— ESPN Stats & Info (@ESPNStatsInfo) October 12, 2014"

The Trojans' Javorius Allen was phenomenal out of the backfield. He had 205 yards rushing and three touchdowns. Allen's effort helped to offset the 395-yard passing performance from Arizona's Anu Solomon.

The Wildcats had their opportunities. They couldn't manage a two-point conversion with 1:07 remaining that would have tied the game—even after a pass-interference penalty gave them a second chance. The Wildcats recovered the subsequent onside kick to breathe new life into their hopes of remaining undefeated.

Solomon got his team within field-goal range, but Arizona kicker Casey Skowron missed the 36-yard attempt wide right. Skowron earned goat status for missing the very makeable attempt, but the play-calling on second and third down before the miss wasn't exactly genius.

Instead of running the ball up the middle on second down to gain a few more yards for Skowron, Arizona elected to have Solomon throw a low-percentage pass to Caleb Jones in the end zone. It fell incomplete, and that took away the team's opportunity to spike the ball on third down.

On the next play, Solomon simply hurled the ball out bounds in what was really just a wasted opportunity.

USC nearly gave the game away with careless penalties throughout the second half. The pass interference on the two-point conversion was just one example. The Trojans were penalized a total of 13 times for 103 yards in the game. Somehow they still hung on for a much-needed win.

With the victory, the Trojans are the top team in the Pac-12 South. USC has been anything but impressive in most of its games this season, but head coach Steve Sarkisian's team has found its way to a 4-2 record overall and a 3-1 mark in the conference.

Many people doubted whether Arizona was for real when it vaulted into the No. 10 spot after knocking off the Ducks. Saturday night's loss makes any of the Wildcats' detractors look as though their criticisms were on point. Losing at home to such an imperfect Trojans team is a bad look.

With so much transition in the top 25 over the last two weeks, it wouldn't be a shock to see the Wildcats drop out of the top 20 with this loss. This one will sting for a while.