NCAA College Football Picks: Week 6 Against the Spread

This week, the football fun kicks into another gear.

A whopping six games will be played between top 25 teams—each of them interconference matchups.

Better yet? Each one makes the cut for this installment of picks! You’re welcome!

Let the good times roll, with lines via CoopersPick.com:

No. 3 Alabama vs. No. 11 Ole Miss

Betting Odds: Alabama -5.5

Alabama has the nation’s ninth-ranked defense to go with a very solid and balanced offense, yet the team has only covered the spread once this season. The Rebels have played a weaker schedule, but their D ranks third and can throw the pigskin around with the best of them.

The road team has covered the spread in five of its last six games between these two SEC rivals.

Pick Against the Spread: Ole Miss is a good team...but not Alabama good. Even on the road, expect the Tide to roll.

No. 4 Oklahoma vs. No. 20 TCU

Betting Odds: Oklahoma -4.5

The Sooners got their first Big 12 win last week but did give up 33 points in doing so. TCU has played weaker opponents, but a defense that ranks second in the nation and only gives up seven points per game is nothing to sneeze at. TCU won its last game against SMU 56-0.

OU is 5-0 ATS in its last five road games, and TCU is only 4-9 ATS in its last 13 home games.

Pick Against the Spread: The Horned Frogs' D will finally be put to the test...one that OU will pass. Go with the Sooners to win and cover.

No. 15 LSU vs. No. 5 Auburn

Betting Odds: Auburn -8

LSU did beat a ranked Wisconsin team in the season opener, but a loss to Mississippi State in conference play has the Tigers at 0-1 in the SEC. A loss to Auburn, and they're likely out of the College Football Playoff picture. They may have the sixth-ranked defense, but in their two games facing solid teams in Wisconsin and MSU, they gave up a combined 58 points. Now they have to contain Auburn and its rushing attack, with dual threats in RB Cameron Artis-Payne and QB Nick Marshall.

Auburn is 5-1-1 ATS in its last seven home games against LSU.

Pick Against the Spread: The Tigers will absolutely win—guaranteed (a little mascot joke there...tough crowd). Take Auburn, even with the points. 

No. 6 Texas A&M vs. No. 12 Mississippi State

Betting Odds: Texas A&M -1

The Bulldogs are undefeated, and they not only beat a Top 10 LSU team in their last game, but they have had two weeks to prepare for this big game. Meanwhile, Texas A&M needed overtime to beat Arkansas, where it gave up 28 points. Aggies QB Kenny Hill leads the fifth-ranked passing offense and for the season, he already has 17 TD and only 2 INT.

Mississippi State is 4-1 ATS in its last five home games, and Texas A&M is 1-4 ATS in the last five games facing a team with a winning record.

Pick Against the Spread: It'll be close, but MSU will prevail.

No. 14 Stanford vs. No. 9 Notre Dame

Betting Odds: Stanford -1

Stanford handed Washington its first loss of the season last week and while the Cardinal offense is decent, the team wins behind the nation's top-ranked defense. Notre Dame's D unit isn't too shabby either, ranking fourth, with a balanced offensive attack to boot. Last season at Stanford, the Cardinal beat the Fighting Irish 27-20.

The road team is 4-1 ATS in the last five games between them, and Stanford is 20-7-1 ATS in its last 28 road games.

Pick Against the Spread: Should be another nail-biter, but take the Cardinal to out-Catholic the Fighting Irish in a win and cover. 

No. 19 Nebraska vs. No. 10 Michigan State

Betting Odds: Michigan State -9.5

The Spartans' only loss this season came against Oregon, while their three wins were all in blowout fashion, admittedly facing much weaker teams. They are the nation’s third highest-scoring team, averaging a staggering 50.3 ppg. At 5-0, the Cornhuskers are working on bringing back the glory days of Tom Osborne's dominant squads, and Ameer Abdullah leads a rushing attack that ranks third in the country. He's fresh off two consecutive games over 200 yards on the ground.

Nebraska is 5-0 ATS in its last five road games and 5-1 ATS in its last six against Michigan State.

Pick Against the Spread: MSU might win, but Nebraska will keep it close and cover the 9.5-point spread.