49ers vs. Bills: Updated Odds, Money Line, Spread, Props to Watch for SNF

One of the most unique environments of the NFL season could be featured on Sunday night in Buffalo.

The Buffalo Bills will host the San Francisco 49ers in below-freezing conditions with multiple feet of snow on the ground.

The Bills usually thrive in this type of environment and the Buffalo crowd should be even more rowdy than it typically is.

The conditions should give the Bills even more of a home-field advantage than they already had against a 49ers team that has been average at best this season.

San Francisco needs a win to keep its standing in the NFC West title race and the NFC wild-card race.

However, it may be difficult for Christian McCaffrey and Co. to take down one of the best teams in football on the road.

Updated SNF Odds

Bryan M. Bennett/Getty Images

ORCHARD PARK, NEW YORK - NOVEMBER 17: James Cook #4 of the Buffalo Bills scores a rushing touchdown against Drue Tranquill #23 of the Kansas City Chiefs during the first quarter at Highmark Stadium on November 17, 2024 in Orchard Park, New York. (Photo by Bryan M. Bennett/Getty Images)

Odds via DraftKings Sportsbook.

Spread: Buffalo (-6)

Over/Under: 44.5

Money Line: Buffalo (-258; bet $258 to win $100); San Francisco (+210; bet $100 to win $210)

San Francisco is one of the worst teams against the spread in the NFL.

The 49ers own a 4-7 ATS mark and they have failed to cover in four of their last five games.

Kyle Shanahan's team was only an underdog once and it failed to cover as a six-point dog without Brock Purdy last week in Green Bay.

Buffalo is 7-4 ATS with a 4-1 covering mark across the last five games.

The Bills have been a favorite of six or more points on three occasions in 2024. They are 1-2 ATS in those games.

Buffalo is also one of the best teams to the over with a 7-4 mark, while San Francisco is 6-5 to the over.

49ers Props to Watch

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GREEN BAY, WISCONSIN - NOVEMBER 24: Christian McCaffrey #23 of the San Francisco 49ers runs with the ball while being chased by Quay Walker #7 of the Green Bay Packers in the third quarter at Lambeau Field on November 24, 2024 in Green Bay, Wisconsin. (Photo by Stacy Revere/Getty Images)

Christian McCaffrey Over/Under 59.5 Rushing Yards & Over/Under 32.5 Receiving Yards

Any conversation about the 49ers starts with Christian McCaffrey's impact on the game.

McCaffrey could be in for a strong performance, despite the conditions, since the Bills give up the most receiving yards to opposing running backs in the NFL.

Buffalo's rushing defense is much better, but it has allowed 69 receptions on 89 targets and 558 receiving yards to running backs.

McCaffrey recorded at least 25 receiving yards in his three appearances this season, but he hasn't gotten going on the ground yet.

The star running back was held under 40 rushing yards in two of his three starts. It may be worth while taking the under on his rushing prop and the over on his receiving prop because of all the trends involved.

Deebo Samuel Over/Under 3.5 Receptions & Over/Under 39.5 Receiving Yards

Deebo Samuel needs to be heavily involved in the 49ers offense for them to leave Buffalo with a win.

Samuel is coming off a quiet afternoon in Green Bay, where he only had one catch for 21 yards.

Three of Samuel's four best receiving performances have come on the road. He has two 100-yard games and a 62-yard outing away from the Bay Area.

He would soar past the over on his receiving-yard prop if he matches those performances on Sunday night.

Bills Props to Watch

Timothy T Ludwig/Getty Images

ORCHARD PARK, NEW YORK - NOVEMBER 17: Khalil Shakir #10 of the Buffalo Bills reacts after making a catch against the Kansas City Chiefs during the third quarter at Highmark Stadium on November 17, 2024 in Orchard Park, New York. (Photo by Timothy T Ludwig/Getty Images)

James Cook Over/Under 64.5 Rushing Yards

James Cook has been a bit of a boom-or-bust player out of the Buffalo backfield in 2024.

He has five games with 70+ rushing yards, but he also has five games with fewer than 45 yards on the ground.

Additionally, four of Cook's five best rushing performances came away from Buffalo. He's only had more than 45 rushing yards at home once this season.

The good news for Cook is that the 49ers have allowed over 100 rushing yards in three of their five road games.

The 49ers have one of the better rushing defense as a whole, but they've been exploited a bit when they travel.

Khalil Shakir Over/Under 5.5 Receptions & Over/Under 54.5 Receiving Yards

Khalil Shakir is Josh Allen's top target in the passing game.

He will have even more importance through the air on Sunday with Keon Coleman listed as questionable and Dalton Kincaid out.

Shakir cleared over 5.5 receptions in each of the last five games. He was targeted at least seven times in all of those contests.

The yardage production has been consistent as well. He had at least 50 receiving yards in every game of that five-game run.

The over on Shakir's receptions and receiving yards should be in play as long as the conditions don't severely limit the passing attacks of both teams.

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