Payne was injured in the first quarter when he appeared to roll his ankle going after a loose ball. He only played four minutes before the injury occurred.
The loss of Payne puts a significant dent in head coach Monty Williams' depth off the bench. Chris Paul's return in Game 3 after missing the previous two games due to health and safety protocols did ease some of the burden on Phoenix's overall guard depth.
Payne was fantastic for the Suns in Game 2 against the Clippers. The 26-year-old scored a career-high 29 points on 12-of-24 shooting and dished out nine assists in Phoenix's 104-103 win. He's averaging 11.8 points and 3.9 assists in 12 playoff games entering Thursday night.
E'Twaun Moore could see time at point guard as the series moves on if Payne is forced to miss future games.
The Suns and Clippers will play Game 4 on Saturday at 9 p.m. ET.