The 33-year-old hasn't played a full season in the NFL since 2013 and played just three games in 2019 after undergoing core muscle surgery in November. He returned in 2020, when he played in the Eagles' first three games of the season. He injured his hamstring in Week 3 and will miss two weeks total.
The three-time Pro Bowler was also out at the end of the 2018 season after he injured his Achilles tendon, but he still managed to lead the league in yards per reception with 18.9.
Jackson signed a three-year deal with the Eagles in 2019 but has only played six total games. So far in 2020, he has 10 catches for 121 yards and no touchdowns.
With the Eagles taking a significant hit injury-wise, with rookie Jalen Reagor moved to the injured reserve, Travis Fulgham, Greg Ward and John Hightower can be expected to slot in alongside Zach Ertz to help the Philadelphia offense manage.