Paraguay and Mexico meet in an international friendly on Tuesday, with the match taking place at Levi's Stadium in Santa Clara, California.
The South American side are in preparation for the 2019 Copa America, but El Tri have not been invited to participate by CONMEBOL.
Mexico have been two-time finalists at the tournament, but they will remain busy under new manager Gerardo Martino with the CONCACAF Gold Cup scheduled for this summer.
Date: Tuesday, March 26
Time: 10 p.m. ET./2 a.m. GMT (Wednesday)
TV Info: Univision (U.S.)
Live Stream: Univision NOW (U.S.)
Odds: Paraguay 7-2, Mexico 5-6, draw 23-10 (via Oddschecker)
Mexico might have been left out of the party set for Brazil at the next Copa, but Paraguay will be huge outsiders for the tournament.
Both teams have experienced unenviable form in recent times. El Tri had won only one of their last six games since the 2018 FIFA World Cup before the weekend triumph over Chile, while Paraguay have not claimed a victory since October 2017.
Mexico produced signs of a recovery in their 3-1 victory over La Roja in San Diego, California, on Saturday.
Former Barcelona head coach Martino took control of the team in January, and the new boss is set to face the team he managed from 2007 to 2011.
Martino has Raul Jimenez to call upon as he rebuilds, and the striker has had a sensational campaign with Wolverhampton Wanderers in the Premier League this season.
The 27-year-old, who is on loan from Benfica, has 12 goals and six assists in his first year in England.
Jimenez opened the scoring with a penalty against Chile, and he gives Mexico potency in attack along with a measure of experience.
Speaking after the win in San Diego, Martinez said he is confident with his plans moving forward, per Rory Carroll of Reuters (via MailOnline):
"I'm hopeful, hopeful for what I see in the field. As coaches, we have two or three trainings before playing a match. When you see the training sessions and have that go into what you're doing that weekend, or FIFA date, it makes me hopeful."
Paraguay also played in California at the weekend, losing 1-0 to Peru on Saturday. The team have a distinct lack of firepower that will give confidence to Mexico.
Los Guaranies trailed for 86 minutes of the game and could find no way of grabbing an equaliser to deny the Peruvians.
Martino's arrival has steadied the Mexico ship in recent months. His squad is blessed with plenty of talent but the addition of a knowledgeable coach could piece together the quality available.
Paraguay are unlikely to test Mexico, and the contest could develop into a one-sided affair.