Chelsea are the highest scorers in the division after City, and they remain unbeaten in the top flight after 12 league games.
Spurs continue to host their matches at the national stadium as they wait on the delayed construction work on their new ground to be completed.
Date: Saturday, Nov. 24
Time: 5:30 p.m. (GMT), 12:30 p.m. (ET)
Odds: Spurs: 7-4, Chelsea: 3-2, draw: 5-2
TV: BT Sport 1 (UK), NBC Sports Live (U.S.)
Odds according to OddsShark.
Three consecutive draws have kept Arsenal behind their major London rivals this season, but the Gunners can keep the pressure on if Spurs and Chelsea drop points on Saturday.
Spurs made their best-ever start to a Premier League campaign this term, but Mauricio Pochettino's men are yet to find their breathtaking best.
Harry Kane has struggled for potency, but the England international still has six goals to his name in the Premier League.
Blues supporters are sure to be happy with new coach Maurizio Sarri's style of play, but the Italian still has lots of work to do on his team's overall balance and chemistry.
Eden Hazard has been Chelsea's primary threat, and Sarri needs an improved all-round contribution from his forward-thinking players.
Alvaro Morata continues to divide critics as Chelsea's striker, but the coach appears content with his development as his No. 9.
According to Charles Perrin of the Daily Express, Sarri complimented the Spain international ahead of the trip to Wembley.
"Morata is a quality player, fast and technically gifted," Sarri said. "He's a sensible person and the difficulties had hurt him. The results and the quality of our football are positive. Eighteen games without a loss in such a competitive reality show that we're on the right track."
Chelsea need to sign a predatory striker in January who will carry the load through the second half of the season in the new year.
Kane's lack of early-season form has seen pundits and fans question Pochettino's lack of spending in the transfer market last summer.
Spurs were the only side to not spend a penny on incoming players, leaving Kane to carry the load after a fatigue-inducing summer with England at the 2018 FIFA World Cup.
The forward has managed to stay fit, and Pochettino should consider bringing in a striker to swell his numbers in January.
If Kane gets injured, Spurs will be in serious trouble as they attempt to maintain a top-four berth throughout the campaign.