EPL Week 5 Predictions: Premier League Picks, Key Players and Fixtures

Liverpool can establish clear daylight at the top of the Premier League if they beat Tottenham Hotspur at Wembley Stadium in Saturday's early kick-off to get the Week 5 fixtures under way.

The Reds already sit at the summit of the English top flight with a superior goal difference to Chelsea and Watford, but clinching victory away to Spurs will be Jurgen Klopp's toughest test of the campaign so far.

Another key clash comes on Saturday evening as a Manchester United side on the rebound look to seal successive wins for the first time this season when they travel to Watford, who are still yet to drop a point after four games.

Champions Manchester City host Fulham on Saturday afternoon, while Arsenal make the trip to Newcastle United, and Southampton host Brighton & Hove Albion in a south-coast special on Monday.

Read on for a breakdown of predictions for which teams will come out on top in the Week 5 schedule, complete with picks for which key players will shine in the upcoming fixtures.

Week 5 Fixtures

Saturday, September 15

Tottenham Hotspur vs. Liverpool, 12:30 p.m. BST/7:30 a.m. ET

Bournemouth vs. Leicester City, 3 p.m. BST/10 a.m. ET

Chelsea vs. Cardiff City, 3 p.m. BST/10 a.m. ET

Huddersfield Town vs. Crystal Palace, 3 p.m. BST/10 a.m. ET

Manchester City vs. Fulham, 3 p.m. BST/10 a.m. ET

Newcastle United vs. Arsenal, 3 p.m. BST/10 a.m. ET

Watford vs. Manchester United, 5:30 p.m. BST/12:30 p.m. ET

Sunday, September 16

Wolverhampton Wanderers vs. Burnley, 1:30 p.m. BST/8:30 a.m. ET

Everton vs. West Ham United, 4 p.m. BST/11 a.m. ET

Monday, September 17

Southampton vs. Brighton & Hove Albion, 8 p.m. BST/3 p.m. ET

Picks are in bold, draw prediction indicated when no bold present.

Lucas Moura, Tottenham Hotspur

After six months of adapting to life in north London, Lucas Moura looks set to play a much greater role in Tottenham's fortunes this season and indicated as much with a player of the month-worthy August in the Premier League.

Spurs' official Twitter account celebrated the Brazilian's stellar run of three goals in two matches, including a brace against Manchester United:

If Tottenham are to get the better of a high-flying Liverpool, they will need more weapons than just Harry Kane, and Lucas is among their best in-form assets.

The former Paris Saint-Germain winger has helped fill the void left by Heung-min Son while he's on international duty with South Korea, and Lucas has shown the motivation for contribute even more, per the official Tottenham website:

"What a month! I'm so happy, so happy! I worked a lot and very hard for this moment and I think the team had a great month with great games.

"The feeling is impossible to explain because I waited a long time for this moment. I need to enjoy it but also to keep working because I believe I have much more to give and I'm sure we will have a successful season because we can, and I believe in my team-mates, I believe in this club. I want to deliver much more."

Ashley Young, Manchester United

Ashley Young looks likely to step back into Jose Mourinho's defence for Saturday's trip to Watford after an in-form Luke Shaw suffered a concussion while on duty for England against Spain on Saturday. Per the Independent, it seems plausible he could return to play "later this month" after showing swift progress.

But it means the Red Devils will be robbed of one of their most impressive performers so far this season for the visit to Vicarage Road, and Young will be in line to make his first appearance of the season at left-back.

Replacing Shaw's sense of urgency bombing down the left side won't be easy for the 33-year-old converted midfielder, particularly after Shaw illustrated his restored confidence with an assist to Marcus Rashford on Saturday, via Sky Football:

Watford full-backs Daryl Janmaat and Jose Holebas have been important figures for boss Javi Gracia this term, and Mourinho may in fact benefit from a more reserved Young caging the former of those Hornets.

However, Shaw will be an inevitable miss for United after showcasing the kind of displays this season that first earned him a move to Old Trafford four years ago.

Adama Traore, Wolverhampton Wanderers

Yet to start a game in 2018-19, Adama Traore could get his first full Premier League bow for Wolverhampton Wanderers on Sunday, when Nuno Espirito Santo's side play host to Burnley.

The Spaniard has had a great effect in each of his three substitute appearances and supplied the winner in the 93rd minute against West Ham United last time out.

Traore told the club's official channel of his pride at netting the late winner at London Stadium:

The 22-year-old arrived at Molineux to great expectations this summer, and his pace could be difficult to handle for a Burnley team still struggling with injuries and the hangover of their UEFA Europa League exit.

Wolves sealed their first Premier League win under Santo at West Ham and will be looking to build further on that, with Traore keen to have his say as part of the starting XI.